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The amount of estrogen in Lupin Estradiol is smaller than in a contraceptive pill, but you could be at higher risk of thrombosis when taking medicine containing estrogen while being a smoker over the age of 35. But, if there aren't any other risk factor as family history of thrombosis of coagulation problems, the risk is still pretty low. Still, try to maintain the lowest dosage possible for estradiol
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Geneviève Duperron suggests meeting with your pharmacist.