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Vitamins and natural products
Major therapeutic interest
Alleviating hot flashes, sweating, and a number of other physical and emotional symptoms of menopause, such as depression, anxiety, and insomnia;
Relieving premenstrual symptoms (PMS) and menstrual pain (dysmenorrhea).
Other therapeutic interest / Traditional Use
Treating urinary tract infections.
Breast cancer, particularly among survivors and women who have been diagnosed (black cohosh can theoretically increase the risk of metastases;
Ovarian cancer, cancer of the uterus, endometriosis, or if close relatives have been diagnosed with hormone-sensitive cancers, the phytoestrogen in black cohosh can spur growth of estrogen-dependent tumors;
Pregnancy and breastfeeding.
Known animal interactions
Decrease cytotoxic effects, which reduces the efficacy of Cisplatin.
May increase cytotoxic effects, which increases the efficacy of doxorubicin (Doxorubicine, Adriamycin, Caelyx) and docetaxel (Taxotere);
May potentiate the toxic effects of particularly hepatotoxic drugs (Actos, Avandia, Prandase, Cordarone, Lipitor, Lescol, Mevacor, Pravachol, Zocor, Imuran, Norvir, Viramune, Tegretol, Tylenol, Voltaren, Lamisil, Sporanox, Nizoral, Tamofen, etc.)
Root and rhizome
Substances with hormonal and estrogen-like properties: phytosterols, phytoestrogens, isoflavones (formononetin); a mix of resins (actein, deoxyactein) and triterpines (cimifugoside); organic acids (salicylic acid, isoferulic acid).
Cimifuga racemosa L., Actaea racemosa L., Bugbane, snakeroot, rattleroot
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