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Vitamins and natural products
Omega-6 type fatty acids: linoleic and gammalinoleic acid (LA, GLA)
Major therapeutic interest
Relieving symptoms of PMS;
Reducing breast pain associated with PMS (mastalgia);
Treating osteoporosis: slows spinal column bone mass and bone mineral loss.
Other therapeutic interest / Traditional Use
Treating autoimmune disorders, particularly multiple sclerosis;
Relieving symptoms of chronic inflammation due to rheumatoid arthritis;
Slowing the progression of diabetic neuropathy;
Treating attention deficit disorder and hyperactivity in children;
Relieving menopause-related symptoms such as hot flashes and excessive sweating;
Treating chronic fatigue syndrome.
Epilepsy and seizure disorder: Lowers the epileptic threshold;
Schizophrenia: May cause convulsions;
Pregnancy: Safety for use during pregnancy has not yet been established.
One case is reported in the literature of a patient who had an epileptic seizure under anesthesia after consuming evening primrose oil. However, the concomitant use of other drugs was also noted.
Known human interactions
Increases the incidence of epileptic seizures when taken with anticonvulsants (Lamictal, Topamax, etc.);
Increases the incidence of epileptic seizures when taken with antipsychotics (Fluanxol, Largactil, etc.)
May heighten the effect of anticoagulant/antithrombotic drugs (Coumadin, Lovenox, heparin, etc.), antiplatelets (Plavix, Ticlid), as well as salicylic acid derivatives (acetylsalicylic acid or ASA, Aspirin, Entrophen, etc.) and other nonsteroidal anti-inflammatory drugs (NSAIDs) (Voltaren, Ibuprofen [Advil, Motrin], Naprosyn, etc.)
Fever plant, King’s cure-all
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