Major therapeutic interest

  • Increasing resistance of veins, decreasing capillary permeability and brittleness, improving microcirculation, and treating various disorders associated with venous insufficiency (swollen and tired legs, hemorrhoids, varicose veins, lymphedema);
  • In ophthalmology, used to improve visual adaptation and retinal microcirculation.

Other therapeutic interest / Traditional Use

  • Used as an antioxidant (antioxidants neutralize free radicals due to pollution, poor diet, overmedication, stress, etc., which are responsible for numerous disorders including circulatory or articulation problems, aging skin, etc.)


  • High blood pressure: concomitant use with vitamin C;
  • Pregnancy and/or breastfeeding: Safety has not yet been established.

Drug Interactions

Known human interactions

  • When taken with vitamin C, grape seed products increase blood pressure (systolic and diastolic).

Suspected interactions

  • May enhance the effect of anticoagulant/antithrombotic drugs (Coumadin, Lovenox, heparin, etc.), antiplatelet drugs (Plavix, Ticlid) and of salicylic acid derivatives (acetylsalicylic acid [ASA], aspirin, Entrophen, etc.) and other nonsteroidal anti-inflammatory drugs (NSAIDs) (Voltaren, Ibuprofen [Advil, Motrin], Naprosyn, etc.)

Parts used

Leaves and seeds of the cultivated vine

Main constituents

  • Polyphenols: Flavonoid and non-flavonoid phenolic antioxidants (complex oligomeric proanthocyanidins [OPC]), organic acids (gallic, ellagic, sinapic), salts, minerals.

Other names

Vitis vinifera, Vine, Wine grape