Major therapeutic interest
- Reducing jet lag;
- Treating sleep disorders in the elderly;
- Relieving secondary insomnia caused by Alzheimer’s disease;
- Treating migraine and Horton’s headache (preventing remission).
Other therapeutic interest / Traditional Use
- Treating sleep disorders linked to intellectual difficulties in children: Reducing sleep onset latency;
- As an additive, reducing the toxic side effects of chemotherapy and radiotherapy.
- Should be administered under medical supervision to people suffering from severe illness (cancer, epilepsy, Alzheimer’s disease, etc.) or children;
- Pregnancy and breastfeeding;
- Women who wish to become pregnant as high doses inhibit ovulation;
- Can aggravate symptoms in asthmatics;
- Should be used with caution by people under age 21 as they are still growing;
- It is recommended to wait 4 to 5 hours after taking it before resuming activities requiring alertness (driving a vehicle, using dangerous machines, working at heights, etc.);
- Diabetes: Use carefully, with closely monitored blood glucose levels;
- Depression: May aggravate dysphoria (mood disturbance).
- Avoid natural source melatonin (of animal origin) due to possible risk of contamination. However, pineal gland extracts are rare on the market and most products are synthetic.
Known human interactions
- Heightens the effect of Coumadin;
- Luvox increases the effect of melatonin;
- Decreases the effect of Procardia XL: increases blood pressure;
- Increases the sedative effect of Prosac;
- Decreases insomnia caused by Inderal and Atenolol;
- May decrease the effect of insulin and oral antidiabetic medications (Actos, Diabeta, Diamicron, Avandia, Glucophage [Metformine], etc.)
- May heighten the effect of anticoagulant/antithrombotic drugs (Coumadin, Lovenox, heparin, etc.), antiplatelets (Plavix, Ticlid), as well as salicylic acid derivatives (acetylsalicylic acid or ASA, Aspirin, Entrophen, etc.) and other nonsteroidal anti-inflammatory drugs (NSAIDs) (Voltaren, Ibuprofen [Advil, Motrin], Naprosyn, etc.);
- May decrease endogenous levels of melatonin with chronic administration of benzodiazepines (insomnia drugs and sedatives);
- May increase the sedative effect of drugs acting on the central nervous system: Ativan, Lectopam, Oxazepam, Valium, Xanax, barbiturates, etc. and alcohol;
- Oral contraceptives may increase the effects of melatonin (Alesse, Diane-35, Marvelon, Min-Ovral, Ortho 0.5/35, Triphasil, etc.);
- May decrease the effect of various categories of immunosuppressants (Imuran, Neoral, Sandimmune, Prograf, etc.) and corticosteroids (Prednisone);
- May modify the metabolism of drugs in various many different categories (Cipro, Luvox, Fluconazole, etc.)
Sleep hormone, darkness hormone, pineal hormone