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Vitamins and natural products
Major therapeutic interest
Reducing nervousness and nerve spasms;
Relieving anxiety and stress;
Other therapeutic interest / Traditional Use
Relieving withdrawal symptoms related to anxiolytic-based treatments;
Relieving withdrawal symptoms related to opiate-based treatments combined with clonidine;
Breastfeeding: Safety has not yet been established;
It is recommended to avoid activities requiring alertness (driving a vehicle, using dangerous machines, working at heights, etc.) after consuming passionflower.
Known animal interactions
Sedative effects have been observed in animals therefore passionflower may increase the action of drugs affecting the central nervous system: Ativan, Lectopam, Oxazepam, Valium, Xanax (Alprazolam), barbiturates, etc.
May heighten the effect of certain antidepressants (nonselective monoamine oxydase inhibitors): Nardil, Parnate, etc.;
May heighten the effect of anticoagulant/antithrombotic drugs (Coumadin, Lovenox, heparin, etc.), antiplatelets (Plavix, Ticlid), as well as salicylic acid derivatives (acetylsalicylic acid or ASA, Aspirin, Entrophen, etc.), and other nonsteroidal anti-inflammatory drugs (NSAIDs) (Voltaren, Ibuprofen [Advil, Motrin], Naprosyn, etc.)
Leaves and flowers
Flavonoids (vitexin, isovitexin, schaftoside, isoschaftoside, apigenol, isoorientin, etc.), alkaloids (harmane, harmone, harmol), maltol.
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