Major therapeutic interest
- Reducing nervousness and nerve spasms;
- Relieving anxiety and stress;
- Decreasing irritability.
Other therapeutic interest / Traditional Use
- Relieving withdrawal symptoms related to anxiolytic-based treatments;
- Relieving withdrawal symptoms related to opiate-based treatments combined with clonidine;
- Reducing hyperactivity;
- Treating insomnia.
- Breastfeeding: Safety has not yet been established;
- It is recommended to avoid activities requiring alertness (driving a vehicle, using dangerous machines, working at heights, etc.) after consuming passionflower.
Known animal interactions
- Sedative effects have been observed in animals therefore passionflower may increase the action of drugs affecting the central nervous system: Ativan, Lectopam, Oxazepam, Valium, Xanax (Alprazolam), barbiturates, etc.
- May heighten the effect of certain antidepressants (nonselective monoamine oxydase inhibitors): Nardil, Parnate, etc.;
- May heighten the effect of anticoagulant/antithrombotic drugs (Coumadin, Lovenox, heparin, etc.), antiplatelets (Plavix, Ticlid), as well as salicylic acid derivatives (acetylsalicylic acid or ASA, Aspirin, Entrophen, etc.), and other nonsteroidal anti-inflammatory drugs (NSAIDs) (Voltaren, Ibuprofen [Advil, Motrin], Naprosyn, etc.)
Leaves and flowers
- Flavonoids (vitexin, isovitexin, schaftoside, isoschaftoside, apigenol, isoorientin, etc.), alkaloids (harmane, harmone, harmol), maltol.
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